URDA: Spain began three days of mourning on Thursday after its second high-speed rail collision this year killed 68 people and injured scores, with relatives desperately seeking news about their loved ones.

One of Europe's deadliest train disasters this century has raised fresh questions about safety on Spain's rail network after the transport minister reported an "error" and "inexplicable circumstances" that led to the crash.

The collision happened in the central region of Castilla-La Mancha on Wednesday morning when a service by state operator Renfe ploughed into the back of a stationary train belonging to private Spanish company Iryo.

Emergency services combed through the wreckage at night to find further victims on the key line linking Madrid with the southern city of Seville, hoisting pieces of mangled metal with cranes, AFP reporters saw.